Probiotics and Dementia
There are several studies examining the effects of probiotics on the cognitive function of Alzheimer’s patients. The results from these trials are mixed. While there is some evidence that they can improve memory and biomarkers of inflammation, many of these findings are controversial. However, further research is needed to determine if probiotics can improve cognitive function. A recent meta-analysis examined five published RCTs to determine whether probiotics improved cognition in MCI and AD patients.
The effect of probiotics on the microbiome remains largely unknown. But if a study is successful, it will provide the best evidence on the topic. One of the most promising findings from animal studies suggests that they can help people with dementia prevent the development of Alzheimer’s disease. The bacterial growth in the gut is one of the main causes of this disease, so targeting the gut microbiota by intervention may be a useful preventative strategy.
In animal studies, probiotics may mitigate neuroinflammation by suppressing the inflammatory response and reducing the activation of microglia. L. pentosus var. plantarum C29 inhibited chronic inflammation in a mouse model. In addition, B. breve A1 administration modulated an overactive immune response, preventing cognitive decline in an AD model mouse.
Another study suggests that probiotics can modify the composition of the gut microbiota. This alteration can protect the brain against oxidative stress and age-related cognitive impairment. Furthermore, research has shown that antibiotics can decrease the inflammatory responses of the hippocampus, which is crucial for cognition. These studies suggest that probiotics may have a positive impact on the hippocampus.
Moreover, they may also reduce the inflammatory response. In a mouse model of Alzheimer’s disease, L. pentosus var. plantarum C29 suppressed chronic inflammation. Similarly, B. breve A1 treatment reduced the excessive immune response and prevented dementia in the model mice. This study is important to determine the effectiveness of probiotics in the treatment of dementia.
There are several types of probiotics that may improve the condition of people with Alzheimer’s. For example, a study on the effect of the lactic acid on fecal microbial composition in AD patients found that the fatty acids in lactic acid were beneficial in regulating neurotransmitter levels. The researchers concluded that a combination of six types of probiotics in humans did not enhance the effects of the anti-inflammatory treatment.
A recent study on Alzheimer’s patients found that a daily dose of probiotics improved their memory and thinking skills. In addition, it has been shown to decrease the level of harmful bacteria in the brain. While the study was small, the results showed that probiotics improved mental performance in patients with AD. This was consistent with the findings in the previous studies. The researchers concluded that this study was the most successful one of its kind.
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